During the Great Depression, a reverend used to feed people there with food which was, without their knowledge, made of humans. The people then rallied against the reverend when they learned of his sin. The legend behind a monster named the Gorger seems to be linked to this story.
In Chapter 5 Torque can choose to escort Hejirah to Canal St. Mission where he was supposed to find his friends. When the two reach the place, Hejirah is shocked to find none of them there. He stops at Canal Street Mission to wait for them while Torque continues on his path to the Grand Theater.